Table 1.
Effects of hypoxia and bed rest on circulating insulin, inflammatory mediators, and TRAIL1.
| Ambulatory |
Bed rest |
P |
|||||
|---|---|---|---|---|---|---|---|
| Normoxia | Hypoxia | Normoxia | Hypoxia | Bed rest effect | Hypoxia effect | Interaction | |
| Insulin (μU⋅mL-1) | 7 ± 1 | 7 ± 1 | 7 ± 1 | 6 ± 1 | 0.85 | 0.93 | 0.27 |
| Glucose (mg⋅dL-1) | 94 ± 2 | 93 ± 1 | 93 ± 1 | 92 ± 1 | 0.35 | 0.57 | 1.00 |
| HOMA2-IR | 0.69 ± 0.01 | 0.68 ± 0.01 | 0.68 ± 0.01 | 0.67 ± 0.01 | 0.35 | 0.56 | 1.00 |
| Homocysteine (μmol × L-1) | 15.3 ± 1.7 | 17.0 ± 1.4 | 14.7 ± 1.4 | 16.2 ± 1.4 | 0.38 | 0.003 | 0.93 |
| C-reactive protein (mg⋅L-1) | 0.6 ± 0.1 | 1.7 ± 1.0 | 0.4 ± 0.1 | 0.8 ± 0.2 | 0.38 | 0.04 | 0.82 |
| Serum amyloid A (μg⋅L-1) | 19.6 ± 0.7 | 28.3 ± 3.0 | 22.9 ± 2.4 | 28.9 ± 3.6 | 0.26 | 0.03 | 0.59 |
| Presepsin (pg/ml) | 91 ± 8 | 70 ± 6* | 101 ± 13 | 107 ± 11 | 0.13 | 0.18 | 0.01 |
| TRAIL (pg/ml) | 80 ± 4 | 107 ± 7* | 82 ± 4 | 94 ± 5 | 0.21 | 0.001 | 0.01 |
HOMA2-IR, Homeostatic Model Assessment of Insulin resistance score; TRAIL, TNF-related apoptosis-inducing ligand. Data are expressed as mean ± SEM. Data were analyzed with the use of a 2-factor repeated measure ANOVA or ANCOVA. Post hoc analysis was performed using Student t-test with Bonferroni correction. ∗p < 0.05 hypoxia versus normoxia.