Table 2.
Effects of hypoxia and bed rest on circulating lipids and enzyme involved in lipid metabolism.
| Ambulatory |
Bed rest |
P |
|||||
|---|---|---|---|---|---|---|---|
| Normoxia | Hypoxia | Normoxia | Hypoxia | Bed rest effect | Hypoxia effect | Interaction | |
| Plasma lipids | |||||||
| Total cholesterol (mg⋅dL-1) | 184 ± 13 | 173 ± 8 | 174 ± 10 | 180 ± 11 | 0.66 | 0.67 | 0.12 |
| LDL-C (mg⋅dL-1) | 117 ± 12 | 110 ± 7 | 110 ± 7 | 121 ± 9* | 0.17 | 0.18 | 0.01 |
| HDL-C (mg⋅dL-1) | 46 ± 10 | 33 ± 2 | 32 ± 2 | 28 ± 2 | <0.01 | 0.02 | 0.65 |
| HDL2-C (mg⋅dL-1) | 19 ± 9 | 9 ± 1 | 10 ± 1 | 7 ± 1 | 0.17 | 0.04 | 0.44 |
| HDL3-C (mg⋅dL-1) | 26 ± 2 | 24 ± 2 | 22 ± 2 | 21 ± 2 | 0.01 | 0.27 | 0.62 |
| HDL2-C/HDL3-C | 0.72 ± 0.28 | 0.41 ± 0.8 | 0.51 ± 0.09 | 0.33 ± 0.03 | 0.03 | 0.19 | 0.001 |
| Total/HDL cholesterol | 4.0 ± 0.5 | 4.4 ± 0.4 | 4.3 ± 0.3 | 4.8 ± 0.4 | <0.001 | <0.01 | 0.78 |
| Triglycerides (mg⋅dL-1) | 94 ± 14 | 113 ± 14 | 109 ± 20 | 102 ± 13 | 0.40 | 0.09 | 0.61 |
| Free fatty acid (μmol/L) | 286 ± 21 | 193 ± 28* | 205 ± 25 | 239 ± 26 | 0.35 | 0.17 | 0.02 |
| Enzymes involved in lipid metabolism | |||||||
| Cholesteryl ester transfer protein (μg⋅mL-1) | 2.81 ± 0.18 | 2.93 ± 0.18 | 2.96 ± 0.25 | 3.09 ± 0.16 | 0.32 | 0.31 | 0.95 |
| Lecithin-cholesterol acyltransferase (ng⋅L-1) | 21.8 ± 4.2 | 20.3 ± 4.3 | 21.7 ± 4.7 | 23.8 ± 6.3 | 0.66 | 0.99 | 0.45 |
| Lipoprotein lipase (ng⋅L-1) | 31.1 ± 3.3 | 24.5 ± 3.7 | 30.5 ± 4.8 | 25.8 ± 3.7 | 0.82 | 0.02 | 0.54 |
| Hepatic lipase (U⋅mL-1) | 0.72 ± 0.10 | 0.79 ± 0.09 | 0.80 ± 0.09 | 0.90 ± 0.08 | 0.15 | 0.04 | 0.81 |
| LPL-to-HL ratio | 56 ± 13 | 33 ± 5 | 39 ± 4 | 30 ± 5 | 0.15 | 0.03 | 0.31 |
Data are expressed as mean ± SEM. Data were analyzed with the use of a 2-factor repeated measure ANOVA or ANCOVA. Post hoc analysis was performed using Student t-test with Bonferroni correction. ∗p < 0.05 hypoxia versus normoxia.