Table 3.
Effects of hypoxia and bed rest on erythrocyte membranes fatty acid composition.
| Ambulatory |
Bed rest |
P |
|||||
|---|---|---|---|---|---|---|---|
| Normoxia | Hypoxia | Normoxia | Hypoxia | Bed rest effect | Hypoxia effect | Interaction | |
| Myristic 14:00 | 0.20 ± 0.02 | 0.31 ± 0.32 | 0.30 ± 0.03 | 0.25 ± 0.02 | 0.45 | 0.08 | 0.01 |
| Palmitic 16:00 | 20.6 ± 0.4 | 20.9 ± 0.3 | 20.6 ± 0.3 | 20.8 ± 0.3 | 0.71 | 0.15 | 0.76 |
| Stearic 18:00 | 18.5 ± 0.2 | 18.4 ± 0.1 | 18.6 ± 0.2 | 18.5 ± 0.1 | 0.58 | 0.27 | 9.64 |
| Palmitoleic 16:1 n7 | 0.25 ± 0.04 | 0.27 ± 0.04 | 0.28 ± 0.04 | 0.26 ± 0.03 | 0.72 | 1.00 | 0.26 |
| Oleic 18:1 n9 | 13.3 ± 0.3 | 12.8 ± 0.3 | 12.8 ± 0.3 | 12.9 ± 0.3 | 0.08 | 0.10 | 0.06 |
| Elaidic trans 18:1n-9 | 1.03 ± 0.04 | 1.02 ± 0.03 | 1.01 ± 0.05 | 1.05 ± 0.05 | 0.70 | 0.45 | 0.14 |
| Eicosenoic 20:1n-9 | 0.31 ± 0.01 | 0.3 ± 0.01 | 0.3 ± 0.01 | 0.31 ± 0.01 | 0.86 | 0.75 | 0.10 |
| Eicosapentaenoic 20:5 n-3 | 0.53 ± 0.04 | 0.58 ± 0.04 | 0.56 ± 0.03 | 0.54 ± 0.04 | 0.94 | 0.50 | 0.10 |
| Docosapentaenoic 22:5 n-3 | 2.50 ± 0.08 | 2.57 ± 0.10 | 2.55 ± 0.09 | 2.57 ± 0.09 | 0.43 | 0.02 | 0.41 |
| Docosahexaenoic 22:6 n-3 | 4.48 ± 0.23 | 4.69 ± 0.26 | 4.63 ± 0.25 | 4.80 ± 0.2 | 0.02 | 0.01 | 0.83 |
| Linoleic 18:2 n6 | 91.9 ± 0.35 | 11.7 ± 0.3 | 11.6 ± 0.35 | 11.39 ± 0.29 | 0.08 | 0.21 | 0.83 |
| Eicosadienoic 20:2 n-6 | 1.09 ± 0.51 | 1.47 ± 0.56 | 1.13 ± 0.19 | 0.89 ± 0.24 | 0.60 | 0.63 | 0.50 |
| Dihomo-γ-linolenic 20:3 n-6 | 1.97 ± 0.13 | 2.04 ± 0.13 | 2.08 ± 0.12 | 2.16 ± 0.13 | 0.001 | 0.02 | 0.98 |
| Arachidonic 20:4 n-6 | 18.1 ± 0.3 | 17.7 ± 0.3* | 18.2 ± 0.2 | 18.4 ± 0.3 | 0.04 | 0.49 | 0.02 |
| Adrenic 22:4 n-6 | 4.15 ± 0.20 | 3.99 ± 0.18 | 4.12 ± 0.17 | 4.17 ± 0.18 | 0.07 | 0.02 | 0.02 |
| Docosapentaenoic 22:5 n-6 | 0.99 ± 0.08 | 1.10 ± 0.13 | 1.17 ± 0.17 | 0.98 ± 0.08 | 0.71 | 0.47 | 0.17 |
| n-3 index1 | 5.01 ± 0.25 | 5.27 ± 0.29 | 5.19 ± 0.26 | 5.34 ± 0.20 | 0.06 | 0.02 | 0.58 |
| Delta-5 desaturase2 | 9.6 ± 0.6 | 9.0 ± 0.5 | 9.1 ± 0.6 | 8.9 ± 0.6 | 0.03 | 0.02 | 0.15 |
Values are percent of total membrane fatty acids (mean ± SEM). 1n-3 index, sum of eicosapentaenoic and docosahexaenoic acids. 2Delta-5 desaturase, ratio between arachidonic and dihomo-g-linolenic acids. Data were analyzed with the use of a 2-factor repeated measure ANOVA or ANCOVA. Post hoc analysis was performed using Student t-test with Bonferroni correction. ∗p < 0.05 hypoxia versus normoxia.