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. 2018 Jul 30;9:1608. doi: 10.3389/fmicb.2018.01608

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Copyright © 2018 Gomes, de Araújo, Vitelli-Avelar, Sathler-Avelar, Lage, Wendling, do Vale, Dias, Elói-Santos, Teixeira-Carvalho and Martins-Filho.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Biomarker signatures upon T. cruzi-antigen recall in vitro. (A) Gray-shaded diagrams were constructed to compile the proportion of volunteers presenting (T. cruzi-antigen/Control Culture) index above the global median cut-off established for the study population. Twenty-two attributes (Fc-γR and Cytokine⁺ cells) were assessed and the percentage of volunteers with a high index determined for indeterminate (IND, = 7) and cardiac (CARD, = 13) Chagas disease patients. (B) The biomarker signatures were assembled as an ascendant curve for each clinical group to identify the relevant attributes as those with frequency above the 50^th percentile (gray-shaded background). The biomarker signature of CARD was further overlaid with the IND-ascendant signature for comparative analysis. Differences were considered for attributes with frequencies confined into distinct 50^th percentiles (dashed-rectangles).

Inline graphic — Biomarker signatures upon T. cruzi-antigen recall in vitro. (A) Gray-shaded diagrams were constructed to compile the proportion of volunteers presenting (T. cruzi-antigen/Control Culture) index above the global median cut-off established for the study population. Twenty-two attributes (Fc-γR and Cytokine⁺ cells) were assessed and the percentage of volunteers with a high index determined for indeterminate (IND, = 7) and cardiac (CARD, = 13) Chagas disease patients. (B) The biomarker signatures were assembled as an ascendant curve for each clinical group to identify the relevant attributes as those with frequency above the 50^th percentile (gray-shaded background). The biomarker signature of CARD was further overlaid with the IND-ascendant signature for comparative analysis. Differences were considered for attributes with frequencies confined into distinct 50^th percentiles (dashed-rectangles).