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. 2018 Jul 30;9:1608. doi: 10.3389/fmicb.2018.01608

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Copyright © 2018 Gomes, de Araújo, Vitelli-Avelar, Sathler-Avelar, Lage, Wendling, do Vale, Dias, Elói-Santos, Teixeira-Carvalho and Martins-Filho.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Biomarker networks upon T. cruzi-antigen recall in vitro. Nodular network layouts were assembled to characterize the association between Fc-γR expression and cytokine profile of peripheral blood leucocytes upon T. cruzi antigen recall in vitro and the anti-live trypomastigote antibody reactivity from IND (A) and CARD (B) Chagas disease patients. Clustered distribution of Fc-γR expression and cytokine microenvironment interfaced by the anti-live T. cruzi trypomastigote IgG reactivity provided an integrative overview of biomarker networks. Neighborhood connections identify the correlation scores between attributes, classified as positive (solid line) or negative (equal dashed line).