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. 2018 Jul 30;9:1723. doi: 10.3389/fmicb.2018.01723

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Copyright © 2018 Zhang, Zong, Wang, Zhu, Hu, Li, Zhang, Chen, Liu and Tan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Fisetin treatment contributes to the survival of infected mice. (A) The effects of fisetin on the survival of mice infected with SC19, and the percentage of mice survival each day. P < 0.001 for comparison of the Δsly group with the SC19Δsly::sly group, and P < 0.001 for comparison of the SC19 group with SC19 + fisetin group. Mice injected with PBS as a control are not shown (the log-rank test). (B) The effect of fisetin on body weight changes of BALB/c mice infected with SC19. The average body weight change of surviving mice was calculated each day. Error bars represented SD from at least three independent experiments.