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. 2018 Jul 30;9:1723. doi: 10.3389/fmicb.2018.01723

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Copyright © 2018 Zhang, Zong, Wang, Zhu, Hu, Li, Zhang, Chen, Liu and Tan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The effect of fisetin on the pathogenicity of SC19. Mice were injected intravenously with 2.5 × 10⁷ CFU of SC19, Δsly, and SC19Δsly::sly, respectively. At 2 h after infection, the group infected with SC19 (12 per group) were injected subcutaneously with 100 mg/kg fisetin at 8 h intervals at the same dosage. The control group (12 per group) was injected with DMSO. At 36 h after infection, the organs (the brain, spleen, and portions of liver) were fixed in 4% of paraformaldehyde for pathological examination. Pathological examination of brain (A), liver (B), and spleen (C) tissues of the infected mice.