Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Jul 26;9:1731. doi: 10.3389/fimmu.2018.01731

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2018 Göbel, Eichler, Wiendl, Chavakis, Kleinschnitz and Meuth.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Overview of the known pathways activated by factor XII (FXII) and the extrinsic coagulation system. Only factors that are involved in inflammation are shown. Activated FXII leads to the cleavage of factor XI, activates the intrinsic, the contact, and complement systems and can bind to CD87. Tissue factor finally leads to the release of thrombin (FIIa) that can directly bind several receptors and activates fibrinogen to fibrin. Deposition of fibrin is regulated by plasmin. Abbreviations: C1-INH, serine protease C1 inhibitor; CD87, urokinase-type plasminogen-activator receptor; tPA, tissue plasminogen activator; PAI-1, plasminogen-activator inhibitor 1; PAR, protease-activated receptor.