Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Jul 26;9:1731. doi: 10.3389/fimmu.2018.01731

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2018 Göbel, Eichler, Wiendl, Chavakis, Kleinschnitz and Meuth.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Overview of the contact system. Activation of factor XII (FXII) leads to the cleavage of plasma prekallikrein to kallikrein. Kallikrein can activate both the complement factors C3 and C5 and also high-molecular-weight kininogen (HMWK). Abbreviations: B1R, bradykinin 1 receptor; B2R, bradykinin 2 receptor; BK, bradykinin; CPK, creatinine phosphokinase.