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Fibrinogen as a mediator of inflammation. Fibrinogen acts on different cells through integrin and non-integrin receptors to induce specific inflammatory effects. Abbreviations: CD11b/CD18, leukocyte integrin adhesion molecule; ICAM-1, intercellular adhesion molecule-1; IL-1β, interleukin-1β; NF-κB, nuclear factor κB; tPA, tissue plasminogen activator; PAI-1, plasminogen-activator inhibitor 1; TNF-α, tumor necrosis factor α.
