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. 2018 Jul 30;9:1686. doi: 10.3389/fimmu.2018.01686

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Copyright © 2018 Avram, Vaisman-Mentesh, Yehezkel, Ashkenazy, Pupko and Wine.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Somatic hypermutation analysis. (A) A histogram showing the frequency of the number of base pair mutations in a next-generation sequencing replicate. The X axis represents the number of mutations (both synonymous and non-synonymous) defined by comparison to the germline genes. (B) The number of non-synonymous (Ka) and synonymous (Ks) mutations and their ratios (Ka/Ks), based on comparison to the germline genes. The Y axis is the number of mutations per codon. Each dot represents a unique variable region nucleotide sequence.