FPR1 |
Formyl peptide receptor 1 |
Pro-inflammatory, antimicrobial defense |
Professional phagocytes |
|
Jacobsen et al. (52) |
|
Combination of CD64, LTF, and RaB33a |
CD64 |
|
Monocytes |
Discriminate active TB, latent TB infection, and healthy status |
|
Fc gamma receptor Ia |
Induce phagocytosis, respiratory burst and antibody-dependent cell-mediated cytotoxicity in monocytes, macrophages, and granulocytes |
|
LTF |
|
Lactoferrin is a transport molecule with high affinity for iron |
Modulates the host response by competing with the microbes for iron |
|
Rab33a |
|
Member of Ras-associated small GTPase family |
Regulates intracellular trafficking |
|
mCD14 receptor |
Membrane bound CD14 receptor—55 kD glycoprotein |
Pattern recognition receptor for Mycobacterium tuberculosis components such as LAM and lipoproteins |
Monocytes |
Biomarker for active TB |
Druszczynska et al. (53) |
|
HMBG1 |
High mobility group box 1 protein also known as Amphoterin |
Pro-inflammatory cytokine, serves as DAMP to alert the innate immune system by recruiting inflammatory cells during disease condition, acts as an immune adjuvant to trigger the response of T cells, dendritic cells, and endothelial cells |
Monocytes |
Biomarker for active TB |
Zeng et al. (54) |
|
IL26 |
Member of interleukin-10 cytokine family |
Inhibitory effect on anti-mycobacterial activity |
Monocytes |
Susceptible gene for TB |
Guerra-Laso et al. (55) |
|
CD163 |
Monocyte/macrophage specific glycoprotein |
Scavenger receptor |
Monocytes |
Biomarker for TB disease progression and monitor treatment efficacy |
Lastrucci et al. (27) |