Table 3. M1 (iNOS/CD68) and M2 (CD163/CD68) Macrophage Polarization Pattern in iTB and CD, with and without Granulomas, as well as in Controls.
| IHC score | Overall | CD | Tuberculosis | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Granuloma positive (n=27) | Granuloma negative (n=52) | P-value | Granuloma positive (n=8) | Granuloma negative (n=42) | P-value | Granuloma positive (n=19) | Granuloma negative (n=10) | P-value | |
| NOS/CD68 score (M1) | <0.05 | <0.05 | >0.05 | ||||||
| <1 | 22 (81.5) | 21 (40.4) | 7 (87.5) | 16 (38.1) | 15 (78.9) | 5 (50.0) | |||
| 1–2 | 3 (11.1) | 30 (57.7) | 1 (12.5) | 26 (61.9) | 2 (10.5) | 4 (40.0) | |||
| 0 | 0 | 1 (1.9) | 0 | 0 | 0 | 1 (10.0) | |||
| Unstained | 2 (7.4) | 0 | 0 | 0 | 2 (10.5) | 0 | |||
| D163/CD68 scores (M2) | >0.05 | >0.05 | >0.05 | ||||||
| <1 | 3 (11.1) | 12 (23.1) | 1 (12.5) | 11 (26.2) | 2 (10.5) | 1 (10.0) | |||
| 1–2 | 20 (74.1) | 29 (55.8) | 7 (87.5) | 7 (87.5) | 13 (68.4) | 6 (60.0) | |||
| >2 | 2 (7.4) | 7 (13.5) | 0 | 5 (11.9) | 2 (10.5) | 2 (20.0) | |||
| Unstained | 2 (7.4) | 4 (7.7) | 0 | 3 (7.1) | 2 (10.5) | 1 (10.0) | |||
Value are presented as number (%).
iTB, intestinal tuberculosis; IHC, immunohistochemical.