Table 5. CRC Molecular Subtype Classification by MSI, CIMP, and Mutations in BRAF and KRAS57.

	Type 1	Type 2	Type 3	Type 4	Type 5
% of CRCs	7	4	26	47	7
MSI	MSI-high	MSS/MSI-low	MSS/MSI-low	MSS/MSI-low	MSS/MSI-low
CIMP	Positive	Positive	Negative	Negative	Negative
BRAF	Mutation	Mutation	Wild-type	Wild-type	Wild-type
KRAS	Wild-type	Wild-type	Mutation	Wild-type	Wild-type
CRC specific 5-yr survival (%)	89.5	49.2	72.4	82.5	93.1
Clinical characteristics	Oldest-onset, female	Old-onset, female	-	Male	Youngest-onset, CRC family history
Site	Proximal colon	Proximal colon	-	Distal colon and rectum	Proximal colon
Proposed molecular pathway	MSI BRAF mutation CIMP-positive	BRAF mutation CIMP-positive	KRAS mutation	Canonical pathway with APC mutation	MSI

CRC, colorectal cancer; MSI, microsatellite instability; CIMP, CpG island methylator phenotype; MSS, microsatellite stable.