Table 11.
Summary of coagulation parameters for the 90-day study on curcumin.
| Group n=20 | PT | APTT | Fibrinogen | |
|---|---|---|---|---|
| mg/kg bw/day | (Sec) | (Sec) | (mg/dl) | |
| Males | ||||
|
| ||||
| Vehicle 0 | Mean | 17.42 | 16.53 | 431.05 |
| SD | 3.34 | 5.86 | 117.12 | |
|
| ||||
| 250 | Mean | 17.29 | 19.03 | 336.03∗∗- |
| SD | 5.08 | 5.16 | 70.20 | |
|
| ||||
| 500 | Mean | 14.84∗∗- | 14.67 | 407.63 |
| SD | 1.99 | 3.13 | 55.83 | |
|
| ||||
| 1000 | Mean | 14.84∗∗-↓ | 13.73 | 355.00∗∗- |
| SD | 1.64 | 2.37 | 62.36 | |
|
| ||||
| Reference Item 1000 | Mean | 16.30 | 13.48∗- | 392.72 |
| SD | 1.91 | 4.35 | 57.90 | |
|
| ||||
| Historical Range | 14.90–21.00 | 10.00–19.60 | 145.30–985.40 | |
|
| ||||
| Females | ||||
|
| ||||
|
Vehicle 0 |
Mean | 15.08 | 16.32 | 268.18 |
| SD | 0.75 | 2.83 | 63.57 | |
|
| ||||
| 250 | Mean | 18.45∗∗+ | 14.47 | 264.64 |
| SD | 1.34 | 3.19 | 188.79 | |
|
| ||||
| 500 | Mean | 17.55∗∗+ | 12.72∗∗- | 241.01 |
| SD | 2.51 | 2.38 | 50.99 | |
|
| ||||
| 1000 | Mean | 14.83↓ | 17.97 | 324.30 |
| SD | 0.66 | 3.50 | 263.26 | |
|
| ||||
| Reference Item 1000 | Mean | 19.20∗∗+ | 16.87 | 246.29 |
| SD | 1.69 | 3.71 | 44.00 | |
|
| ||||
| Historical Range | 14.50–21.90 | 7.40–21.00 | 243.50–758.10 | |
N= number of animals, ∗+/∗-= statistically significant increase/decrease as compared to vehicle control (p<0.05), ∗∗+/∗∗-= statistically significant increase/decrease as compared to vehicle control (p<0.01), and ↓ = statistically significant decrease as compared to the reference item group (p<0.05).
APTT, activated partial thromboplastin time; PT, prothrombin time.