Table 4.

Summary data for chromosome aberrations.

Short Term Exposure								Continuous Exposure
In the Absence of Metabolic Activation System				In the Presence of Metabolic Activation System				In Absence of Metabolic Activation System
Concentration ( µ g/mL)	% Aberrated Cells (Structural)		%   Numerical Aberration Mean ± SD	Concentration ( µ g/mL)	% Aberrated Cells (Structural)		%   Numerical Aberration Mean ± SD	Concentration ( µ g/mL)	% Aberrated Cells (Structural)		%   Numerical Aberration Mean±SD
	Including Gap #   Mean ± SD	Excluding Gap #   Mean ± SD			Including Gap #   Mean ± SD	Excluding Gap #   Mean ± SD			Including Gap #   Mean ± SD	Excluding Gap #   Mean ± SD
Vehicle Control 0.0	1.00 ± 0.47	0.67 ± 0.94	0.40 ± 0.57	Vehicle Control 0.0	1.33 ± 0.00	1.00 ± 0.47	0.00 ± 0.00	Vehicle Control 0.0	1.34 ± 0.94	1.34 ± 0.94	0.00 ± 0.00
10.0	1.33 ± 0.00	1.00 ± 0.47	0.40 ± 0.00	6.3	0.67 ± 0.00	0.34 ± 0.47	1.00 ± 0.28	6.3	1.67 ± 0.47	1.33 ± 0.00	0.20 ± 0.28
20.0	3.34 ± 1.89	3.00 ± 1.41	0.60 ± 0.28	12.5	2.00 ± 0.95	1.67 ± 0.47	0.40 ± 0.00	12.5	1.33 ± 0.00	1.33 ± 0.00	0.20 ± 0.28
40.0	1.67 ± 0.47	1.67 ± 0.47	0.40 ± 0.00	25.0	4.33∗ ± 1.41	4.33∗ ± 1.41	0.60 ± 0.28	25.0	2.33 ± 1.41	2.00 ± 0.95	0.20 ± 0.28
MMC 0.25	12.33∗∗  ± 0.47	12.33∗∗  ± 0.47	0.00 ± 0.00	CPA 12.5	17.67∗∗  ± 3.30	17.33∗∗  ± 2.83	0.20 ±0.28	MMC 0.25	11.33∗∗  ± 0.00	11.33∗∗  ± 0.00	0.00 ± 0.00
Historical Vehicle   Control♮	0.89–1.61	0.40–0.94	NA	Historical Vehicle Control♮	0.82–1.39	0.46–1.04	NA	Historical Vehicle Control♮	0.76–1.61	0.39–1.07	NA

CPA, cyclophosphamide, positive control; MMC, mitomycin C, positive control; SD, standard deviation; VC, vehicle control (dimethyl sulfoxide); ∗, significantly increased at 5 % in two sided Fisher's Exact Test; ∗∗, significantly increased at 1 % in two sided Fisher's Exact Test; #, number of aberrant cells; ^♮, numbers reported are the 95% confidence interval; NA, not applicable.