Table 4.
Pharmacokinetic parameters of silybin after the oral administration ofsilymarin SMEDDS soft capsules compared with conventional capsules from the published study.
| Pharmacokinetics Parameters | Silybin (mean ± SD) | ||
|---|---|---|---|
| Silymarin SMEDDS soft capsules | Published study | ||
| Conventional capsule ∗ | Conventional ∗∗ | ||
| tmax (h)# | 0.80 (0.25-1.67) | 1.50 (0.50-8.0)# | 1.5 |
| Cmax (/ngml) | 812.43 ± 434.07 | 137.40 ± 51.83 | 167.3 |
| AUC0-t (ng.h/ml) | 658.80 ± 266.23 | 294.80 ± 95.58 | N/A |
| AUC0-inf (ng.h/ml) | 676.98 ± 268.34 | 299.10 ± 96.00 | 406.5 |
Note. ∗ Published study conducted by Zhu and coworkers in 2013 [15].
∗∗ Published study conducted by Brinda and coworkers in 2012 [16].
# Median (range).
Cmax: maximum observed plasma concentration; AUC0-t: area under the plasma concentration versus time curve up to the last; AUC0-inf: area under the plasma concentration versus time curve with the concentration extrapolated based on the elimination rate constant; tmax: time to Cmax; N/A: not available.