Amomum villosum reduced body weight and fat accumulation in HFD-fed rats. Effects of A. villosum treatment on (a) body weight, (b) food intake, (c) white fat, (d) brown fat, (e) liver index, and (f) liver biopsy. (a–e) The difference between groups was evaluated using one-way analysis of variance (ANOVA, n = 10). Asterisks (∗) indicate a significant difference from the model group, ∗P < 0.05, ∗∗P < 0.01, ∗∗∗P < 0.001. (f) Representative images (200× magnification, hematoxylin and eosin stain) of hepatic histology in CON, MOD, EZE, WEAV.M, VOAV.M, and BA.M groups. No obvious fatty degeneration was observed in hepatocytes in the CON group. Obvious edema and steatosis were observed in hepatocytes after being fed a high-fat diet for 16 weeks. They were markedly relieved in VOVA.M and BA.M groups.