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Local application of SCAPs for periodontitis treatment in a minipig periodontal model. (a-b) Bone defects of 3 mm × 5 mm × 7 mm were generated in the mesial region of the bilateral mandibular first molars (a). Three-dimensional CT images showed obvious bone defect in experimental region (b). (c-d) Intraoral manifestations demonstrating tissue regeneration in 0.9% NaCl group (c) and SCAPs group 12 weeks after the treatment (d).
