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Protease-induced hyperexcitability of nociceptors. Rheobase of mouse DRG neurons preincubated with Dy4 (A, B, D, and F, dynamin inhibitor), PS2 (C, E, and G, clathrin inhibitor), or vehicle control (Con). Neurons were challenged with trypsin (A–C), NE (D and E), or CS (F and G), washed, and rheobase was measured 0 or 30 min later. (A) Representative traces. Rh, rheobase. (B–G) Mean responses. *P < 0.05, **P < 0.01, ***P < 0.001. Numbers in bars denote neuron numbers.
