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. 2018 Jul 16;115(31):8019–8024. doi: 10.1073/pnas.1805538115

Fig. 1.

Fig. 1.

Schwann cell O-GlcNAcylation is required for peripheral nerve remyelination after injury. (A) Semithin sections of sciatic nerves: uninjured (U), 14 d (C14), or 30 d (C30) after nerve crush injury. Note unmyelinated/thinly myelinated fibers (asterisks) in OGT-SCKO nerves (ogt) at C14 and at C30. (B) Electron micrographs of injured sciatic nerves at 14 d after injury (C14). (C) Quantification of remyelination (% myelinated axons) in A. ***P < 0.001. n = 3 mice per genotype each injury time point. (D) Analysis of g ratios of remyelinated fibers at C30 in A. ***P < 0.001. n = 3 mice per genotype each injury time point. (E) Immunostaining of injured sciatic nerves at C14 using antibodies to detect myelin (MBP), axons (NF), and nuclei (DAPI). Arrows, myelinated axons. n = 3 mice per genotype. (Scale bars: A, 10 µm; B, 1 µm; E, 20 µm.)