Table 3.

Comparison of CM and CFD model approaches.

	CFD
	Euler-Euler	Euler-Lagrange	Compartmentation
Prediction purpose	Reactor heterogeneity	Cell-Environment Interaction	Reactor design
Computational effort	High	High	Low
Level of detail	High	High	Low
Prediction accuracy of flow regime	High	High	Low
Single cell tracking	No	Yes	Yes
Integrable model size	Coarse-grained small-scale	Coarse-grained small-scale	Genome-scale
Amount of particles	High	Low (<10%)	High