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. Author manuscript; available in PMC: 2018 Aug 6.
Published in final edited form as: ChemMedChem. 2018 Jan 10;13(2):138–146. doi: 10.1002/cmdc.201700697

Figure 2.

Figure 2.

Syntheses of iodo precursors for radiolabelling 16–19. Conditions: a) acetyl chloride or isobutyryl chloride, AlCl3, DCM, RT, 8 h. b) (1) pyridine, trichloroacetyl chloride, dioxane, 80 °C, 2.5 h; (2) MeOH, NaOH, 80 °C, 30 min.c) N-hydroxyacetamidine, NaH, THF, RT, 1 h. d) epichlorohydrin, KOH, TBAB, RT, 1 h. e) ArOH, DMAP, DCM, 120 °C, 1 h. f) Dess-Martin periodinane, DCM, RT, 4 h.