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. Author manuscript; available in PMC: 2018 Aug 6.
Published in final edited form as: ChemMedChem. 2018 Jan 10;13(2):138–146. doi: 10.1002/cmdc.201700697

Table 2.

Radioligand in vitro properties.

Radioligand IC50[a] (nM) logD fP(%) Stability in buffer(%) Stability in rat brain homogenate(%)
[11C]1 12 2.10±0.01 1.46±0.01 98.9±0.2 96.9
[11C]2 10 2.43±0.01 1.24±0.01 98.4±0.2 97.5
[11C]3 6.1 2.07±0.02 n.d.[b] 99.7±0.2 n.d.
[11C]4 2.1 1.94±0.15 0.072±0.001 80.3±3.4 104
[a]

Data from references [19] and [20].

[b]

n.d. = not determined.