FIGURE 7.

Avidity chart of malaria vaccinee serum binding to CSP Ags. (A–C) The mean binding responses of mAbs AB334 and AB236 at 25-nM concentration (star) and postvaccination (day C1) serum (at 1:50 dilution) of group 1 (circles) and group 2 (squares) VAC055 study participant interaction with CSP-FL (A), NANP6 (B), and PF16 (C) are plotted against the respective mean dissociation rates. The mean values were calculated from 10 replicate measurements. In (B), dashed circle is shown to emphasize the clustering of low NANP6 binders away from high and medium binders. The arrows shown in (B) indicate the vaccinees in group 1 with low- and high-avidity Ab responses against NANP6.