Table 1.

Chemical composition of extracellular matrix in human tissue

Extracellular matrix tissue source	Component				Reference
	Fibronectin	Laminin	Collagen	Other components
Human mesenchymal stem cell	Fibronectin (FN1)	Laminin	Collagen I–II	Fibulin-1, fibrillin-1, filamin-A, perlecan	[42]
			Collagen VI (α1), collagen VI (α2), collagen VI (α3), collagen XII (α1)	Periostin, tenascin C, transforming growth factor-betainduced protein ig-h3, transglutaminase 2, thrombospondin-1 versican
Human adipocyte	Fibronectin (FN) (cold-insoluble globulin)	L aminin α2, laminin α4, laminin β1, laminin β2, laminin γ1	Collagen I (α1), collagen I (α2), collagen III (α1), collagen IV* (α1), collagen V (α1), collagen VI (α1), collagen VI (α2), collagen VI (α3), collagen XIII (α1), collagen XIV (α1) (undulin), collagen XV (α1), collagen XVIII (α1)	Proteoglycan IV, agrecan, decortin, cartilage intermediate layer protein, mimecan (osteoglycin), nidogen 1 (entactin), nidogen 2 (osteonidogen), periostin, dermaportin, tenascin C and X	[29]
	Fibulin-1
Human breast cancer	Oncofetal fibronectin	Laminin 111, laminin 332	Collagen I, collagen III, collagen IV–V	Fibrilin, fibulin, elastin, epigrilin, entactin, vitronectin, proteoglycans, hyaluronan, glycoprotein	[35]
Ligament tissue	Fibronectin I	Laminin β1	Collagen I, collagen III, collagen IV–VI, collagen XI–XII	Proteoglycans IV, versican, vibrilin I, decorin, bigylcan sulphated glyco-saminosglycans, elastin, small rich leucine protein	[43-46]
Lymphoid tissue	Fibronectin	Laminin α1, laminin α2, laminin α4, laminin α5, laminin γ, laminin β1, laminin β2, pan-laminin, laminin 332	Collagen I, collagen III, collagen IV	Tenascin	[47,48]
Bone	Fibronectin, vitronectin	Laminin	Collagen I, collagen III	Osteopontin, osteocalcin, osteonectin, chondroitin sulphate, thrombospodin I, thrombospodin II, secreted protein acidic and rich in cysteine, R-spondin, bone sialoprotein, dentin matrix acidic phosphoprotein-1, matrix extracellular phosphoglycoprotein, matrix-gla protein, periostin, aspirin, biglycan, decoran, keratocan, matrix metallopreoteinase (MMP2 & 14)	[31,49]
Human corneal tissue (epithelial and stroma)	Fibronectin	Laminin 5 (α3β3γ2)	Collagen I–IX	K eratan sulphate, chondroitin sulphate, N-acetylglucosamine	[36,37,50]
		Laminin 10 (α5β1γ1)	Collagen XII–XIV
			Collagen XVII–XVIII
Skin tissue	Fibronectin (in basement membrane)	Laminin α3β3γ2	Collagen I, III, IV–VII	E lastic fiber (elastin, microfibrilar component, fibrillar), glycosaminoglycans, heparan sulfate, nidogen	[32,51]
		Laminin α5β1γ1