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. 2018 Jul 30;9:885. doi: 10.3389/fphys.2018.00885

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Copyright © 2018 Kim, Sharma and Vatamaniuk.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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ΔNTE-HMT-1 exerts a dominant negative effect on the function of the full-length ABCB6/HMT-1 in Cd resistance. Wild-type worms or the hmt-1 mutant expressing the indicated constructs when grown in the presence of the indicated concentrations of cadmium (Cd). Cd sensitivity is expressed as the percentage of worms that have reached the adult stage of the development. The total number (n) of worms tested is shown above each bar. The error bar shows SD. Asterisks (^∗∗p < 0.01, ^∗∗∗p < 0.001) indicate statistically significant differences between worms grown without vs. with CdCl₂.