Table 3.
Performance characteristics of immunochemical and guaiac fecal occult blood tests for detection of advanced colorectal neoplasia (N=1006)
| Advanced colorectal neoplasia on colonoscopy | Positivity (%) | Sensitivitya | Specificitya | PPVa | Likelihood ratioa | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Yes | No | (%) | (95% CI)b | (%) | (95% CI)b | (%) | (95% CI)b | (95% CI)b | |||
| Stool test result | |||||||||||
| InSure FIT | |||||||||||
| Positive | 14 | 30 | 4.5 | 26.3 | (15.9–40.7) | 96.8 | (95.5–97.8) | 31.8 | (19.0–47.1) | 8.5 | (4.4–14.3) |
| Negative | 39 | 904 | |||||||||
| OC FIT-CHEK | |||||||||||
| Positive | 8 | 20 | 3.0 | 15.1 | (6.7–26.1) | 97.8 | (96.6–98.6) | 28.7 | (12.5–46.4) | 7.2 | (2.6–14.3) |
| Negative | 45 | 874 | |||||||||
| Hemoccult II SENSA | |||||||||||
| Positive | 4 | 13 | 1.7 | 7.4 | (1.9–17.0) | 98.6 | (97.7–99.2) | 23.6 | (6.3–50.0) | 5.8 | (1.1–16.0) |
| Negative | 51 | 938 | |||||||||
| Difference between test resultsc | |||||||||||
| InSure FIT–OC FIT-CHEK | 11.2 | (0.4, 24.2) | −1.0 | (−2.4, 0.5) | |||||||
| InSure FIT–Hemoccult II SENSA | 18.9 | (10.2, 32.6) | −1.8 | (−3.3, −0.7) | |||||||
| OC FIT-CHEK–Hemoccult II SENSA | 7.8 | (−1.4, 19.1) | −0.9 | (−2.2, 0.3) | |||||||
CI, confidence interval; PPV, positive predictive value.
a
Point estimates were based on bias-corrected estimates from 2,000 bootstrap samples drawn from the original sample.
b
Ninety-five percent confidence intervals were calculated using the adjusted bootstrap percentile method (bias-corrected and accelerated).
c
Difference in sensitivity or specificity between the stool tests.