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. 2018 Jul 30;9:817. doi: 10.3389/fphar.2018.00817

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Copyright © 2018 Gangadaran, Hong, Oh, Rajendran, Kalimuthu, Son, Gopal, Zhu, Baek, Jeong, Lee, Lee and Ahn.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Characterization of RBC-EMs and RBC-Exos, and comparison of their vesicular yields (A) Representative images of RBC-Exos and RBC-EMs isolated from the same number of RBCs. (B) Morphology of RBC-EMs and ^99mTc-RBC-EMs was examined by TEM. (C) Nanoparticle tracking analysis of RBC-Exos. (D) The yields of RBC-Exos and RBC-EMs measured as particle numbers (n = 3). (E) RBC-Exos and RBC-EMs total protein content (n = 3). The values are expressed as mean ± SD, ^∗∗∗P < 0.001, (Student’s t-test).