Table 3.
Association between level of eGFR and in-hospital pneumonia in stroke patients
| Pneumonia type | Level of eGFR (mL/min/1.73 m2)
|
|||||
|---|---|---|---|---|---|---|
| ≥90 (n=1,106) | 60–89 (n=4,866) | 45–59 (n=2,177) | 30–44 (n=1,427) | 15–29 (n=596) | <15 (n=157) | |
| Overall | (sHR; 95% CI) | |||||
| Events, % (n) | 8.6 (96) | 13.0 (631) | 15.7 (342) | 20.0 (285) | 21.0 (131) | 21.7 (34) |
| Model 1 | Ref. [1] | 0.75 (0.60–0.95) | 0.76 (0.58–0.97) | 0.89 (0.68–1.16) | 0.99 (0.74–1.33) | 1.24 (0.82–1.85) |
| Model 2 | Ref. [1] | 0.80 (0.65–1.00) | 0.80 (0.62–1.03) | 0.93 (0.72–1.22) | 0.96 (0.72–1.29) | 1.15 (0.77–1.73) |
| Model 3 | Ref. [1] | 0.79 (0.63–0.99) | 0.78 (0.61–1.00) | 0.92 (0.71–1.20) | 0.94 (0.70–1.26) | 1.12 (0.75–1.68) |
| Model 4 | Ref. [1] | 0.78 (0.62–0.99) | 0.76 (0.59–0.99) | 0.89 (0.68–1.16) | 0.90 (0.66–1.20) | 1.06 (0.71–1.60) |
| Aspiration | (sHR; 95% CI) | |||||
| Events, % (n) | 5.7 (63) | 7.8 (378) | 10.7 (232) | 11.5 (164) | 12.8 (76) | 12.1 (19) |
| Model 1 | Ref. [1] | 0.67 (0.50–0.89) | 0.75 (0.55–1.03) | 0.76 (0.54–1.06) | 0.86 (0.60–1.25) | 1.05 (0.62–1.78) |
| Model 2 | Ref. [1] | 0.71 (0.53–0.96) | 0.79 (0.57–1.08) | 0.80 (0.57–1.11) | 0.84 (0.58–1.22) | 0.99 (0.58–1.68) |
| Model 3 | Ref. [1] | 0.71 (0.53–0.96) | 0.78 (0.57–1.07) | 0.79 (0.57–1.10) | 0.83 (0.57–1.20) | 0.97 (0.57–1.65) |
| Model 4 | Ref. [1] | 0.69 (0.52–0.93) | 0.75 (0.55–1.04) | 0.76 (0.54–1.05) | 0.77 (0.53–1.12) | 0.90 (0.53–1.54) |
| Nonaspiration | (sHR; 95% CI) | |||||
| Events, % (n) | 2.9 (33) | 5.2 (253) | 5.1 (110) | 8.5 (121) | 9.2 (55) | 9.6 (15) |
| Model 1 | Ref. [1] | 0.89 (0.60–1.32) | 0.73 (0.47–1.12) | 1.14 (0.74–1.76) | 1.27 (0.79–2.05) | 1.6 (0.89–3.16) |
| Model 2 | Ref. [1] | 0.98 (0.66–1.45) | 0.79 (0.51–1.22) | 1.21 (0.78–1.87) | 1.22 (0.76–1.96) | 1.51 (0.80–2.85) |
| Model 3 | Ref. [1] | 0.97 (0.65–1.43) | 0.78 (0.50–1.20) | 1.19 (0.77–1.83) | 1.19 (0.74–1.91) | 1.46 (0.78–2.76) |
| Model 4 | Ref. [1] | 0.96 (0.65–1.43) | 0.76 (0.50–1.18) | 1.16 (0.75–1.80) | 1.13 (0.70–1.84) | 1.42 (0.75–2.68) |
Notes: Model 1: age, sex. Model 2: Model 1+history of stroke, stroke type, prestroke modified Rankin score, Oxfordshire Community Stroke Project (stroke severity). Model 3: Model 2+asthma, COPD, lung cancer. Model 4: Model 3+diabetes, hypertension, dyslipidemia, coronary heart disease, heart failure, arterial fibrillation.
Abbreviations: eGFP, estimated glomerular filtration rate; RRR, relative risk ratio; sHR, subdistribution hazard ratio.