Skip to main content
. 2018 Aug 1;11:159–171. doi: 10.2147/JAA.S151849

Figure 1.

Figure 1

Pulmonary function mechanics are improved in GC021109-treated mice.

Notes: Acute MCh-induced pulmonary function response curves in 10-week-old mice after 6 weeks of treatment with saline, GC021109, HDM (80 µg), or HDM + GC021109 at either 10 or 100 µg/kg weight/dose. Pulmonary resistance in the (A) GC021109 (10 µg/kg weight/dose) treatment group and (B) GC021109 (100 µg/kg weight/dose) treatment group. Pulmonary compliance in the (C) GC021109 (10 µg/kg weight/dose) treatment group and (D) GC021109 (100 µg/kg weight/dose) treatment group. Pulmonary elastance in the (E) GC021109 (10 µg/kg weight/dose) treatment group and (F) GC021109 (100 µg/kg weight/dose) treatment group. The mice treated with HDM alone exhibited significant changes in pulmonary resistance, compliance, and elastance curves in a pattern consistent with asthma. The combination of HDM and GC021109 reversed these changes. The effect appeared stronger with the 100 µg/kg weight/dose GC021109 dose. GC021109 given with saline was not different from saline alone. Treatment groups: 1 – saline, 2 – saline + GC021109, 3 – HDM + GC021109, 4 – HDM. Values are mean ± SEM of N=4–5 mice per group. *P<0.05, saline control compared to HDM; @P<0.05, HDM + GC021109 compared to HDM; $P<0.01, HDM + GC021109 compared to HDM; ‡P<0.01, saline control compared to HDM; ▼P<0.005, HDM + GC021109 compared to HDM; #P<0.005, saline control compared to HDM.

Abbreviations: HDM, house dust mite; MCh, methacholine; SEM, standard error of means.