Figure 2.

GC021109 prevents HDM-induced peribronchiolar and perivascular inflammatory cell infiltration.

Notes: Representative photomicrographs of hematoxylin/eosin-stained lung (5-µm sections) from mice treated 6 weeks with either saline, HDM, saline + GC021109 (100 µg/kg weight/dose), or HDM + GC021109 (100 µg/kg weight/dose). Arrows point to inflammatory cell infiltration in the peribronchiolar and perivascular space. Inflammatory cells were prominently increased by HDM treatment. This response was absent in mice treated concomitantly with HDM and GC021109. *Vascular lumen, **bronchiolar lumen. Bar represents 50 µm.

Abbreviation: HDM, house dust mite.