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. 2018 Aug 1;11:159–171. doi: 10.2147/JAA.S151849

Figure 6.

Figure 6

Peribronchial thickness identified by micro-CT scan is increased by HDM and ameliorated by HDM + GC021109.

Notes: Mice treated with saline, HDM, or HDM + GC021109 (100 µg/kg weight/dose) underwent micro-CT scanning to image pulmonary airways. Images were captured at peak inspiration. Peribronchial thickness at the level of the third-generation bronchi on coronal images was measured in both the coronal and corresponding transverse axial planes. Only bronchi whose shape indicated parallel (coronal) or perpendicular (sagittal, i.e. transverse axis) orientation to the image plane were measured. Data represent mean ± SEM; N=3 mice (1–2 measurements per lung). @P<0.10, compared to saline of same image orientation; *P<0.05, compared to HDM of same image orientation; ^P<0.005, compared to saline of same image orientation; ‡P<0.005, compared to HDM of same image orientation.

Abbreviations: HDM, house dust mite; SEM, standard error of means; CT, computed tomography.