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. 2018 Aug 1;13:4433–4443. doi: 10.2147/IJN.S168268

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© 2018 Zhao et al. This work is published and licensed by Dove Medical Press Limited

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Schematic diagram of the synthesis of AP613-1-mediated USPIO (Apt-USPIO). OA-coated USPIO nanoparticles are modified with DSPE-PEG₂₀₀₀-NH₂. Amino moieties (NH₂-) of USPIO nanoparticles and 5′ carboxyl (-COOH) of AP613-1 are reacted to construct the Apt-USPIO probe.

Abbreviations: Apt-USPIO, aptamer-mediated USPIO; DSPE-PEG₂₀₀₀-NH₂, 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[amino(polyethylene glycol)-2000]; EDC, 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride; NHS, N-hydroxysuccinimide; OA, oleic acid; USPIO, ultrasmall superparamagnetic iron oxide.