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Cytotoxicity of the USPIO and Apt-USPIO nanoparticles. In vitro viability study of Huh-7 cells in the presence of samples with varied concentrations for (A) 24 and (B) 48 h, and that of L-02 cells for (C) 24 and (D) 48 h. There is no significant reduction of cell viability with the increased concentration of USPIO or Apt-USPIO and the prolonged incubation time.
Abbreviations: Apt-USPIO, aptamer-mediated USPIO; USPIO, ultrasmall superparamagnetic iron oxide.
