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. 2018 Aug 1;13:4433–4443. doi: 10.2147/IJN.S168268

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© 2018 Zhao et al. This work is published and licensed by Dove Medical Press Limited

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In vivo MRI of xenograft tumors. (A) In vivo T₂-weighted MRI of the HCC xenograft models after injection of USPIO or Apt-USPIO. (B) T₂-weighted MR signal intensities of the Huh-7 tumors significantly decrease in the experimental (Apt-USPIO) group as compared to the control (USPIO) group. (C) RSE values in the experimental group are significantly higher than the control group at different time points. (D) Coronal and axial T₂-weighted MR images of tumor-bearing mice before and after intravenous injection show significant negative enhancement of the tumors (red circles) at different time points in the Apt-USPIO group. (E) There is no decline in the signal intensities of the tumors (yellow circles) in the corresponding USPIO group.

Abbreviations: Apt-USPIO, aptamer-mediated USPIO; HCC, hepatocellular carcinoma; MRI, magnetic resonance imaging; RSE, relative signal enhancement; USPIO, ultrasmall superparamagnetic iron oxide.