Table 1.
PCB Metabolites as Inhibitors of SULT1E1
| PCB Metabolite a | IC50 (nM) |
|---|---|
| 4’-OH-PCB 3 | 1300 ± 490 |
| 4’-PCB 3 Sulfate | > 10,000 b |
| 4’-OH-PCB 8 | 18 ± 6 |
| 4’-PCB 8 Sulfate | > 10,000 b |
| 4-OH-PCB 11 | 7.2 ± 1.4 |
| 4-PCB 11 Sulfate | > 10,000 b |
| 4’-OH-PCB 25 | 7.3 ± 1.7 |
| 4’-PCB 25 Sulfate | 440 ± 100 |
| 4-OH-PCB 52 | 19 ± 7 |
| 4-PCB 52 Sulfate | > 10,000 b |
a
The concentrations of PCB metabolites for the determination of IC50 values were 0.01 nM to 10 μM at an estradiol concentration of 7nM.
b
No inhibition was detected at a 10 μM concentration of the PCB metabolites.