Table 2.
PCB Metabolites as Inhibitors of SULT2A1
| PCB Metabolite a | IC50 (μM) |
|---|---|
| 4’-OH-PCB 3 | 12 ± 5 |
| 4’-PCB 3 Sulfate | > 100 b |
| 4’-OH-PCB 8 | 1.5 ± 0.3 |
| 4’-PCB 8 Sulfate | 46 ± 11 |
| 4-OH-PCB 11 | 23 ± 4 |
| 4-PCB 11 Sulfate | > 100 b |
| 4’-OH-PCB 25 | 4.9 ± 0.9 |
| 4’-PCB 25 Sulfate | > 100 b |
| 4-OH-PCB 52 | 1.3 ± 0.4 |
| 4-PCB 52 Sulfate | 30 ± 11 |
a
The concentrations of PCB metabolites for the determination of IC50 values were 0.01 μM to 200 μM for inhibition of SULT2A1 at a concentration of 1.0 μM DHEA.
b
The IC50 value for the PCB metabolite was greater than 100 μM.