Table 2. Morpholino oligomers evaluated.
| Gene name | Activity | Name | Oligomer sequence |
|---|---|---|---|
| Scramble Control Oligomer | N/A | Scr | CCTCTTACCTCAGTTACAATTTATA |
| X antigen family member 1 (XAGE1B) | Enhances anti-apoptotic effect of TNF-α | XAGE1B | CTGTGTGGTTCTGTGTTTGT |
| Cyclin D1 (CCND1) | Regulates cell cycle progression | CCND1 | CTCGGCTCTCGCTTCTGCTG |
| RNA binding motif protein 11 (RBM11) | Tissue-specific regulator of gene splicing | RBM11 | AATGAAGTAGGAGCTGAGACCCC |
| Cytochrome P450 family 4 subfamily F member 22 (CYP4F22) | Regulates acyl-ceramide metabolism | CYP4F22-1 CYP4F22-2 CYP4F22-3 |
TCTGTGATGGGCAGCATCCT TTGGGTTCACTGTCTTCTTCCTTGC TGCCATGCACAAGACGATGACCCA |
| Phosphoglycerate dehydrogenase (PHGDH) | Plays essential role in serine biosynthesis | PHGDH-1 PHGDH-2 |
CGCTGTGAGTAGAAGTACCTAAGCC AAGCCGCAGGCACATCATTGCTTAC |
| Insulin like growth factor binding protein 2 (IGFBP-2) | Enhance or attenuate pro-survival, IGF signaling | IGFBP2-1 IGFBP2-2 IGFBP2-3 IGFBP2-4 |
CTCCTCCGCTTCTTCCTCCT TGATGTCTGTCCAACAAGCGTCCAT TGCTCAGTGACCTTCTCCCGGAAC TGGTTCTCCACCAGGCCTCCTTC |