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. 2018 Jul 17;9(55):30610–30623. doi: 10.18632/oncotarget.25753

Figure 3. Alterations in derived N-glycan traits.

Figure 3

Derived N-glycan traits were calculated to evaluate glycosylation changes between CRC and healthy controls. Significant changes were observed for (A) Mono-fucosylated di-antennary glycans, which were lower in CRC as compared to controls, (B) Tetra-antennary glycans, (C) Multi-fucosylated tri-antennary glycans, (D) α2,6-sialylation/antenna and (E) α2,3-sialylation/antenna in fucosylated tri-antennary glycans, which were all elevated in CRC. Differences were evaluated by Mann-Whitney U test for the discovery and the first validation set. The third evaluation consisted of paired univariate analyses in the postoperative validation set using the Wilcoxon Signed Ranks test. In the latter comparison, preoperative sera from the cases in the validation set were compared to postoperative sera from the same individuals, but now with a cancer free status. Univariate analyses were performed in SPSS (Version 20, IBM, NY, USA). Boxplots consistently indicate the mean ± standard error (SE). Significances are indicated and correspond to * p-value < 0.05, ** p-value < 0.01, *** p-value < 0.001.