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. 2018 Jul 17;9(55):30610–30623. doi: 10.18632/oncotarget.25753

Table 2. Validated colorectal cancer associated serum N-glycan alterations.

N-Glycans Discovery set Validation sets
Cases vs. controls Cases vs. controls Cases vs. post-operative cases
Composition Structure* m/z [M+Na]+ Alteration in CRC Fold Change Case vs Control VIP p-valuea Z-scoreb p-valuea Z-score p-valuec Z-score
H4N4F1 graphic file with name oncotarget-09-30610-i001.jpg 1647.59 down 0.73 1.5 4.00E−08 −5.5 1.00E−03 −3.3 1.00E−03 −3.2
H5N4 graphic file with name oncotarget-09-30610-i002.jpg 1663.58 down 0.72 1.6 2.80E−08 −5.6 4.00E−04 −3.5 7.00E−03 −2.7
H5N4F1 graphic file with name oncotarget-09-30610-i003.jpg 1809.64 down 0.59 2.0 3.50E−15 −7.9 2.20E−05 −4.2 4.00E−03 −2.9
H4N4E1 graphic file with name oncotarget-09-30610-i004.jpg 1820.66 down 0.81 1.4 2.80E−06 −4.7 4.00E−03 −2.9 5.70E−02 −1.9
H4N5F1 graphic file with name oncotarget-09-30610-i005.jpg 1850.67 down 0.81 1.2 4.40E−07 −5.1 1.20E−05 −4.4 1.50E−04 −3.8
H5N5F1 graphic file with name oncotarget-09-30610-i006.jpg 2012.72 down 0.80 1.3 1.50E−07 −5.3 4.80E−04 −3.5 2.00E−04 −3.7
H5N4F1L1 graphic file with name oncotarget-09-30610-i007.jpg 2082.72 down 0.81 2.1 1.60E−09 −6 5.00E−05 −4.1 1.10E−05 −4.4
H5N4F1E1 graphic file with name oncotarget-09-30610-i008.jpg 2128.77 down 0.77 1.9 9.30E−13 −7.1 1.00E−03 −3.2 1.00E−03 −3.4
H5N4F1L2 graphic file with name oncotarget-09-30610-i009.jpg 2355.81 down 0.89 1.6 2.40E−04 −3.7 3.00E−03 −2.9 7.80E−02 −1.8
H6N5F1E1L1 graphic file with name oncotarget-09-30610-i010.jpg 2766.98 up 1.23 1.1 2.90E−04 −3.6 2.00E−04 −3.7 4.50E−06 −4.6
H6N5E3 graphic file with name oncotarget-09-30610-i011.jpg 2986.09 up 1.27 1.4 2.90E−06 −4.7 2.00E−03 −3.1 1.00E−04 −3.9
H6N5F1E1L2 graphic file with name oncotarget-09-30610-i012.jpg 3040.07 up 1.31 1.3 1.70E−05 −4.3 7.30E−05 −4 8.90E−06 −4.4
H6N5F1E2L1 graphic file with name oncotarget-09-30610-i013.jpg 3086.11 up 1.48 1.4 4.40E−07 −5 7.00E−05 −4 2.50E−07 −5.2
H6N5F1E3 graphic file with name oncotarget-09-30610-i014.jpg 3132.15 up 1.37 1.5 1.90E−06 −4.8 2.00E−04 −3.7 4.90E−05 −4.1
H6N5F2E1L2 graphic file with name oncotarget-09-30610-i015.jpg 3186.13 up 1.39 1.2 1.30E−04 −3.8 2.20E−04 −3.7 2.20E−06 −4.7
H6N5F2E2L1 graphic file with name oncotarget-09-30610-i016.jpg 3232.17 up 1.38 1.3 2.10E−05 −4.3 1.20E−04 −3.8 4.7E−05 −4.1
H7N6F1E1L2 graphic file with name oncotarget-09-30610-i017.jpg 3405.20 up 1.29 1.2 5.00E−05 −4.1 3.00E−05 −4.2 8.70E−05 −3.9
H9N8E1 graphic file with name oncotarget-09-30610-i018.jpg 3443.24 up 1.27 1.2 1.00E−03 −3.4 3.50E−04 −3.6 3.10E−05 −4.2
H7N6F1E2L1 graphic file with name oncotarget-09-30610-i019.jpg 3451.24 up 1.29 1.4 1.00E−03 −3.4 7.50E−05 −4 1.40E−04 −3.8
H7N6F1E2L2 graphic file with name oncotarget-09-30610-i020.jpg 3724.33 up 1.43 1.4 3.20E−06 −4.7 1.30E−05 −4.4 3.60E−05 −4.1

*structural isomers cannot be excluded

aMann-Whitney U test, p-value < 0.01

bZ-score: indicates how many standard deviations an element is from the mean

cWilcoxon signed ranks test, p-value < 0.1; m/z, mass to charge ratio; M, mass; Na, sodium; VIP, variable importance in projection; CRC, colorectal cancer; H, hexose; N, N-acetylhexosamine; F, fucose; E, α2,6-linked sialic acid; L, α2,3-linked sialic acid.