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Both S1P and S2P proteases are necessary for ER stress-mediated TOR activation. S2R+ cells were transfected with double-strand (ds) RNA of S1P and S2P, separately or together. The transfected cells were cultured for 2 days, and treated with serum-free media (A) without ER stress, or (B) with ER stress. Then, Western blot analysis was performed with phospho(Thr398)-specific S6K antibody or tubulin antibody. Site-1 protease (S1P), Site-2 protease (S2P).
