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Examples of IDRs in human proteins: ( A ) Breast cancer type 1 susceptibility protein (BRCA1), ( B ) Cellular tumor antigen p53 (Oncoprotein p53), ( C ) T-cell surface glycoprotein CD4 (Disprot), ( D ) Secondary structure information (UniProtKB) and ( E ) mutation histogram (COSMIC) of BRCA1 is provided to illustrate mutations in the unstructured regions.
