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Schematic representation of the impact of functional mutation on protein misfolding, folding, aggregation, domain swapping, macromolecular crowding and protein degradation pathways. Structure of misfolded rat CD2 structure (PDB ID: 1A6P) and normal CD2 (PDB ID: 1HNG) is used for representing misfolded and folded structures. Functional variant is represented using red asterisk.
