Table 1.

AUC of logistic regression model to predict synergistic combinations: direction-based expression similarity scores

	6 h, IC20 (48 h)	6 h, IC20 (24 h)	12 h, IC20 (48 h)	12 h, IC20 (24 h)	24 h, IC20 (48 h)	24 h, IC20 (24 h)
All	0.43 [0.70]	0.70 [0.77]	0.47 [0.71]	0.67 [0.76]	0.56 [0.73]	0.56 [0.71]
FC > 1.1 or < 1/1.1	0.55 [0.71]	0.77 [0.80]	0.43 [0.70]	0.69 [0.77]	0.66 [0.76]	0.68 [0.74]
FC > 1.2 or < 1/1.2	0.69 [0.75]	0.81 [0.83]	0.62 [0.73]	0.74 [0.78]	0.79 [0.82]	0.78 [0.79]
FC > 1.3 or < 1/1.3	0.75 [0.77]	0.81 [0.81]	0.74 [0.78]	0.74 [0.79]	0.84 [0.85]	0.79 [0.82]
FC > 1.4 or < 1/1.4	0.77 [0.77]	0.82 [0.80]	0.76 [0.80]	0.73 [0.78]	0.85 [0.84]	0.79 [0.81]

AUCs are shown using gene expression similarity only and combining gene expression similarity with structural similarity (in brackets). FC, fold change.