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Mutation of top-ranking residues via positional mutual information greatly decreases cefotaxime drug resistance. The five highest-scoring residues for cefotaxime (orange online) and meropenem (yellow with residues in both sets as red) were selected for alanine mutagenesis. These were located both inside and distant from the drug pocket (A). Six of the eight mutants displayed a >2-fold drop in resistance (Color version of this figure is available at Bioinformatics online.)
