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. 2016 Jul 27;32(22):3420–3427. doi: 10.1093/bioinformatics/btw492

Table 1.

Top-scoring residues via positional excess mutual information

Rank	CTX-M9:cefotaxime	CTX-M9:meropenem
1	T235^a^,^b	T235^a^,^b
2	N132^a	G236^b^,^c
3	T71^a^,^b^,^c	T216
4	Y264^b	T71^a^,^b^,^c
5	N245^a^,^b	R276^a^,^c
6	D246^a^,^b	S130^b^,^c
7	N104^a^,^b^,^c	A219^a^,^b^,^c
8	Y234^a	D246^a^,^b
9	I221^b	Y234^a
10	N106^c	Y73^a^,^b^,^c
11	R222	M68^b
12	Y73^a^,^b^,^c	N132^a
13	D233^b	A218^a
14	Y105^a^,^b	C69^b
15	V103^a^,^c	S237^a^,^c
16	S220^c	N214^a
17	A219^a,^bc	L119
18	Y60	N245^a^,^b
19	A218^a	A125
20	A263	N104^a^,^b^,^c
21	Q128^a^,^b	E166^c
22	D131^a^,^b	T133
23	V262^b	V103^a^,^c
24	L225	Y105^a^,^b
25	N214^a	G217
26	V46^b	T215^b
27	L33^b	L127^b
28	S237^a^,^c	Q128^a^,^b
29	A231	L102^b
30	R276^a^,^c	D131^a^,^b
31	S72^b	P167
32		E110^b

^aShared between CTX-M9:cefotaxime and CTX-M9:meropenem.

^bConserved residue.

^cResidue mutated experimentally; altered drug resistance observed.