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. 2018 Aug 1;12:2361–2369. doi: 10.2147/DDDT.S168588

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© 2018 Chaikomon et al. This work is published and licensed by Dove Medical Press Limited

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Conjugation scheme and characterization of DexDOX.

Notes: (A) The one-pot, two-step conjugation process, first step: a reaction of DOX and 2-iminothiolane at 1:1 mole, second step: equal molarity of dexamethasone was added. The reactions were performed in DMSO at RT. (B) Representative image of TLC showing lane 1: DOX, lane 2: dexamethasone, lane 3: 2-iminothiolane; lane 4: reactions products; fraction A targeted products, fraction B, lane 5: DexDOX (purified fraction a), lane 6: DOX + dexamethasone. (C) Representative color of DexDOX and DOX in DMSO solution. (D) APCI mass-spectroscopy analysis of DexDOX.

Abbreviations: RT, room temperature; TLC, thin-layer chromatography; APCI, atmospheric pressure chemical ionization; DOX, doxorubicin.