Table 4.

Effect of SLIGRL-NH₂ on the histological features of loperamide-induced constipated rats (mean ± standard deviation)

Groups	Thickness of the mucosa layer (μm)	Number of goblet cells (ea)	Number of enterocytes (ea)
Control	401 ± 37.8	87.2 ± 8.2	124.1 ± 9.5
Constipation	125 ± 13.7	52.3 ± 4.1	79.6 ± 8.5
SLIGRL-NH2 low	274 ± 25.3*	60.6 ± 4.9	90.1 ± 9.2
SLIGRL-NH2 high	385 ± 39.2**	79.5 ± 7.3**	118.5 ± 9.7*
Prucalopride	411 ± 29.3**	82.4 ± 9.1**	116.4 ± 8.9*

Notes:

^*p<0.05,

^**p<0.01 versus constipation group. “ea” indicates that the microscope image observed at 200×.