Table 1.

Antiproliferative potency of natural products and first generation analogs in TNBC cell lines

	GI50 ± SD (μM)
Cmpd	MDA-MB-453	MDA-MB-231	HCC1937	HCC70	BT-549
Natural 1	40 ± 30	>200	n.d.	>200	n.d.
Synthetic 1	60 ± 40	n.d.	n.d.	n.d.	n.d.
Natural 2	17 ± 4	92	77	100 ± 50	n.d.
Synthetic 2	11 ± 7	29 ± 4	13.7	16.8	27 ± 3
3	13 ± 2	19 ± 6	8.7	11	20 ± 8
4	29 ± 9	n.d.	n.d.	n.d.	n.d.
10	10 ± 3	13 ± 1	16 ± 4	19 ± 5	20 ± 8
11	8 ± 2	30 ± 4	35.0 ± 0.4	40 ± 10	25.3 ± 0.4
12	12 ± 4	15 ± 1	17 ± 2	20 ± 10	30 ± 6
13	17 ± 4	95	66	152	50 ± 10
14	35 ± 6	50 ± 20	40 ± 10	32	52
15	>100	>100	>100	>100	>100
16	40 ± 10	53 ± 8	41 ± 8	42 ± 8	43 ± 5
17	2 ± 1	9.0 ± 0.6	6 ± 2	8 ± 2	9 ± 1
18	12 ± 6	21 ± 3	21 ± 3	24 ± 2	25 ± 3
19	31 ± 6	50 ± 30	51.2	70 ± 30	80 ± 50
20	>100	>100	>100	>100	>100